Protein Name:
14-3-3 protein zeta/delta
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UniprotKB/SwissProt ID: P63104 (P63104)
Gene Name:
YWHAZ
Organism: Homo sapiens (Human)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P63104
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
189 |
YEILNSPEKA C SLAKTAFDEA |
CCHHHHHHHH H HHHHHHHHHH |
5.19% |
19483679
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| 2 |
25 |
QAERYDDMAA C MKSVTEQGAE |
CCHHHHHHHH H HHHHHHHHHH |
2.27% |
25040305
22126794
2212679
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| 3 |
94 |
EKIETELRDI C NDVLSLLEKF |
CCHHHHHHHH H HHHHHHHHHH |
4.1% |
19483679
25040305
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