Protein Name:
14-3-3 protein zeta/delta
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UniprotKB/SwissProt ID: P63101 (P63101)
Gene Name:
Ywhaz
Organism: Mus musculus (Mouse)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P63101
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
189 |
YEILNSPEKA C SLAKTAFDEA |
CCHHHHHHHH H HHHHHHHHHH |
5.19% |
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| 2 |
25 |
QAERYDDMAA C MKSVTEQGAE |
CCHHHHHHHH H HHHHHHHHHH |
2.27% |
24926564
20925432
21278135
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| 3 |
94 |
EKIETELRDI C NDVLSLLEKF |
CCHHHHHHHH H HHHHHHHHHH |
4.1% |
22588120
21278135
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