UniprotKB/SwissProt ID: P63094 (P63094)
Gene Name:
Gnas
Organism: Mus musculus (Mouse)
Function: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:21467038). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21467038). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:21467038). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:21467038). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (By similarity). Functions downstream of beta-adrenergic receptors (By similarity). Stimulates the Ras signaling pathway via RAPGEF2 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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