Protein Name:
Complexin-1
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UniprotKB/SwissProt ID: P63040 (P63040)
Gene Name:
Cplx1
Organism: Mus musculus (Mouse)
Function: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:23345244). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:23345244). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior (PubMed:15126625, PubMed:16000319)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Perikaryon. Presynapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P63040
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
105 |
TRPKKAIPPG C GDEPEEEDES |
CCHHHHHHHC C CCHHHHHHCC |
8.39% |
24895380
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