Protein Name:
60 kDa heat shock protein, mitochondrial
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UniprotKB/SwissProt ID: P63038 (P63038)
Gene Name:
Hspd1
Organism: Mus musculus (Mouse)
Function: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P63038
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
237 |
YFINTSKGQK C EFQDAYVLLS |
CCCCHHHHHH H CHHHHHHHHH |
4.94% |
24895380
24926564
22588120
20925432
21278135
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| 2 |
442 |
VEEGIVLGGG C ALLRCIPALD |
CCCCHHHHHH H CHHHHHHHHH |
2.46% |
24895380
24926564
22588120
21278135
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| 3 |
447 |
VLGGGCALLR C IPALDSLKPA |
CCCCHHHHHH H CHHHHHHHHH |
4.39% |
21278135
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