Protein Name:
Cytochrome c, somatic
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UniprotKB/SwissProt ID: P62897 (P62897)
Gene Name:
Cycs
Organism: Mus musculus (Mouse)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion intermembrane space
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P62897
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
15 |
EKGKKIFVQK C AQCHTVEKGG |
CCCHHHCCEE E EEECCCCCEE |
1.44% |
22178444
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| 2 |
18 |
KKIFVQKCAQ C HTVEKGGKHK |
CCCHHHCCEE E EEECCCCCEE |
1.22% |
22178444
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