Protein Name:
Ubiquitin-conjugating enzyme E2 D2
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UniprotKB/SwissProt ID: P62838 (P62838)
Gene Name:
Ube2d2
Organism: Mus musculus (Mouse)
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P62838
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
107 |
LTISKVLLSI C SLLCDPNPDD |
CCHHHHHHHH H HHHHCCCCCC |
1.79% |
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| 2 |
111 |
KVLLSICSLL C DPNPDDPLVP |
CCHHHHHHHH H HHHHCCCCCC |
11.23% |
20925432
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| 3 |
85 |
HPNINSNGSI C LDILRSQWSP |
CCHHHHHHHH H HHHHCCCCCC |
2.75% |
20925432
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