Protein Name:
Ras-related protein Rap-1A
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UniprotKB/SwissProt ID: P62835 (P62835)
Gene Name:
Rap1a
Organism: Mus musculus (Mouse)
Function: Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (By similarity). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell junction. Cytoplasm. Cytoplasm, perinuclear region. Early endosome. Late endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P62835
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
118 |
DVPMILVGNK C DLEDERVVGK |
CCEEEEEEEC C CCCCCHHHHH |
9.29% |
21278135
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| 2 |
48 |
DSYRKQVEVD C QQCMLEILDT |
CCEEEEEEEC C CCCCCHHHHH |
3.48% |
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