Protein Name:
Ras-related protein Rab-1A
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UniprotKB/SwissProt ID: P62821 (P62821)
Gene Name:
Rab1a
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:22854043). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:22854043). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (By similarity). Required to modulate the compacted morphology of the Golgi. Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (PubMed:22854043)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P62821
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
126 |
NVNKLLVGNK C DLTTKKVVDY |
CCCCCHHHHH H HHHHHHCCCC |
6.34% |
20925432
21278135
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| 2 |
26 |
LIGDSGVGKS C LLLRFADDTY |
CCCCCHHHHH H HHHHHHCCCC |
3.37% |
21278135
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