Protein Name:
Rho-related GTP-binding protein RhoB
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UniprotKB/SwissProt ID: P62747 (P62747)
Gene Name:
Rhob
Organism: Rattus norvegicus (Rat)
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Late endosome membrane. Cell membrane. Nucleus. Cleavage furrow
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Graphical Visualization of S-nitrosylation Sites:
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