Protein Name:
Rho-related GTP-binding protein RhoB
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UniprotKB/SwissProt ID: P62745 (P62745)
Gene Name:
RHOB
Organism: Homo sapiens (Human)
Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Late endosome membrane. Cell membrane. Nucleus. Cleavage furrow
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P62745
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
107 |
EKWVPEVKHF C PNVPIILVAN |
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| 2 |
159 |
VRIQAYDYLE C SAKTKEGVRE |
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| 3 |
20 |
VVGDGACGKT C LLIVFSKDEF |
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