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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Small nuclear ribonucleoprotein Sm D3

UniprotKB/SwissProt ID: P62318 (P62318)

Gene Name: SNRPD3

Organism: Homo sapiens (Human)

Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027141 LSm4/Sm_D1/D3
IPR010920 LSM_dom_sf
IPR047575 Sm
IPR001163 Sm_dom_euk/arc
IPR034099 SmD3

The S-nitrosylation sites of P62318

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 20 LHEAEGHIVT C ETNTGEVYRG  CCCCCCEEEE E ECCCEEEEEE  4.15% 25040305
2 41 KLIEAEDNMN C QMSNITVTYR  CCCCCCEEEE E ECCCEEEEEE  2.21%