Protein Name:
14-3-3 protein epsilon
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UniprotKB/SwissProt ID: P62258 (P62258)
Gene Name:
YWHAE
Organism: Homo sapiens (Human)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P62258
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
97 |
QMVETELKLI C CDILDVLDKH |
CCHHHHHHHH H HHHHHHHHHH |
2.18% |
22178444
19483679
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| 2 |
98 |
MVETELKLIC C DILDVLDKHL |
CCHHHHHHHH H HHHHHHHHHH |
2.64% |
22178444
19483679
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