Protein Name:
NPC intracellular cholesterol transporter 2
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UniprotKB/SwissProt ID: P61916 (P61916)
Gene Name:
NPC2
Organism: Homo sapiens (Human)
Function: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531, PubMed:18772377, PubMed:29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Endoplasmic reticulum. Lysosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P61916
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
27 |
AQAEPVQFKD C GSVDGVIKEV |
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| 2 |
42 |
GVIKEVNVSP C PTQPCQLSKG |
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