Protein Name:
V-type proton ATPase subunit d 1
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UniprotKB/SwissProt ID: P61421 (P61421)
Gene Name:
ATP6V0D1
Organism: Homo sapiens (Human)
Function: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:30374053, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Lysosome membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P61421
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
197 |
KAYLESFYKF C TLLGGTTADA |
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| 2 |
244 |
KEDRAKLFPH C GRLYPEGLAQ |
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| 3 |
335 |
ECRNIVWIAE C IAQRHRAKID |
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| 4 |
39 |
SQADYLNLVQ C ETLEDLKLHL |
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