Protein Name:
ATP-binding cassette sub-family E member 1
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UniprotKB/SwissProt ID: P61222 (P61222)
Gene Name:
Abce1
Organism: Mus musculus (Mouse)
Function: Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (By similarity). Able to hydrolyze ATP, GTP, UTP and CTP (By similarity). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (By similarity). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (By similarity). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (By similarity). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (By similarity). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:10866653). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P61222
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
201 |
KDETKTQAIV C QQLDLTHLKE |
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| 2 |
227 |
LSGGELQRFA C AVVCIQKADI |
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| 3 |
65 |
CIGCGICIKK C PFGALSIVNL |
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