Protein Name:
Actin-related protein 3
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UniprotKB/SwissProt ID: P61158 (P61158)
Gene Name:
ACTR3
Organism: Homo sapiens (Human)
Function: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P61158
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
12 |
AGRLPACVVD C GTGYTKLGYA |
CCCCCCEEEE E CCCCCEECCC |
3.38% |
2212679
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| 2 |
189 |
PVAEGYVIGS C IKHIPIAGRD |
CCCCCCEEEE E CCCCCEECCC |
3.97% |
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| 3 |
235 |
KAVKERYSYV C PDLVKEFNKY |
CCCCCCEEEE E CCCCCEECCC |
1.32% |
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| 4 |
34 |
NTEPQFIIPS C IAIKESAKVG |
CCCCCCEEEE E CCCCCEECCC |
1.72% |
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| 5 |
408 |
KDYEEIGPSI C RHNPVFGVMS |
CCCCCCEEEE E CCCCCEECCC |
4.2% |
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| 6 |
8 |
---MAGRLPA C VVDCGTGYTK |
CCCCCCEEEE E CCCCCEECCC |
2.64% |
2212679
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