Protein Name:
Ras-related protein Rab-14
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UniprotKB/SwissProt ID: P61106 (P61106)
Gene Name:
RAB14
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:22595670). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (PubMed:22595670). Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (PubMed:20534812). Interaction with RAB11FIP1 may function in the process of neurite formation (PubMed:26032412)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Recycling endosome. Early endosome membrane. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P61106
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
26 |
IIGDMGVGKS C LLHQFTEKKF |
CCCCCCCHHH E EEEEEECCCC |
5.51% |
19483679
37478858
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| 2 |
40 |
QFTEKKFMAD C PHTIGVEFGT |
CCCCCCCHHH E EEEEEECCCC |
1.61% |
37478858
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