Protein Name:
NEDD8-conjugating enzyme Ubc12
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UniprotKB/SwissProt ID: P61081 (P61081)
Gene Name:
UBE2M
Organism: Homo sapiens (Human)
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P61081
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
111 |
HPNIDLEGNV C LNILREDWKP |
CCCCCCCCHH H HHHHCCCCCC |
2.53% |
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| 2 |
181 |
GYIGSTYFER C LK-------- |
CCCCCCCCHH H HHHHCCCCCC |
4.47% |
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| 3 |
47 |
DINELNLPKT C DISFSDPDDL |
CCCCCCCCHH H HHHHCCCCCC |
5.66% |
19483679
21278135
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| 4 |
65 |
DDLLNFKLVI C PDEGFYKSGK |
CCCCCCCCHH H HHHHCCCCCC |
2.44% |
19483679
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| 5 |
95 |
GYPHDPPKVK C ETMVYHPNID |
CCCCCCCCHH H HHHHCCCCCC |
6.19% |
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