Protein Name:
Eukaryotic initiation factor 4A-I
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UniprotKB/SwissProt ID: P60843 (P60843)
Gene Name:
Eif4a1
Organism: Mus musculus (Mouse)
Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, Stress granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P60843
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
131 |
MALGDYMGAS C HACIGGTNVR |
CCCCCCCCCC C CCCCCCCCCC |
2.03% |
20925432
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| 2 |
134 |
GDYMGASCHA C IGGTNVRAEV |
CCCCCCCCCC C CCCCCCCCCC |
1.01% |
20925432
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| 3 |
66 |
SAIQQRAILP C IKGYDVIAQA |
CCCCCCCCCC C CCCCCCCCCC |
4.5% |
20925432
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