Protein Name:
Eukaryotic initiation factor 4A-I
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UniprotKB/SwissProt ID: P60842 (P60842)
Gene Name:
EIF4A1
Organism: Homo sapiens (Human)
Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, Stress granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P60842
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
131 |
MALGDYMGAS C HACIGGTNVR |
CCCCCCCCCC C CCCCCCCCCC |
2.03% |
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| 2 |
134 |
GDYMGASCHA C IGGTNVRAEV |
CCCCCCCCCC C CCCCCCCCCC |
1.01% |
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| 3 |
66 |
SAIQQRAILP C IKGYDVIAQA |
CCCCCCCCCC C CCCCCCCCCC |
4.5% |
19483679
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