Protein Name:
Actin, cytoplasmic 1
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UniprotKB/SwissProt ID: P60709 (P60709)
Gene Name:
ACTB
Organism: Homo sapiens (Human)
Function: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P60709
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
17 |
ALVVDNGSGM C KAGFAGDDAP |
CCCCCEEEEE E CCCCCEECCC |
2.89% |
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| 2 |
217 |
EIVRDIKEKL C YVALDFEQEM |
CCCCCEEEEE E CCCCCEECCC |
3.68% |
25040305
21278135
|
| 3 |
257 |
VITIGNERFR C PEALFQPSFL |
CCCCCEEEEE E CCCCCEECCC |
3.08% |
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| 4 |
272 |
FQPSFLGMES C GIHETTFNSI |
CCCCCEEEEE E CCCCCEECCC |
3.65% |
25040305
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| 5 |
285 |
HETTFNSIMK C DVDIRKDLYA |
CCCCCEEEEE E CCCCCEECCC |
3.22% |
19483679
21278135
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| 6 |
374 |
ESGPSIVHRK C F--------- |
CCCCCEEEEE E CCCCCEECCC |
5.02% |
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