Protein Name:
Ras-related protein Rab-2B
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UniprotKB/SwissProt ID: P59279 (P59279)
Gene Name:
Rab2b
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states (PubMed:28930687). In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:28930687). Regulates the compacted morphology of the Golgi (By similarity). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (PubMed:28930687). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28063257)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, autophagosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P59279
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
21 |
IIGDTGVGKS C LLLQFTDKRF |
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