UniprotKB/SwissProt ID: P58242 (P58242)
Gene Name:
Smpdl3b
Organism: Mus musculus (Mouse)
Function: Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity (PubMed:26095358). Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358, PubMed:27687724). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358, PubMed:27687724). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (PubMed:27687724)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Cell membrane
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