UniprotKB/SwissProt ID: P57716 (P57716)
Gene Name:
Ncstn
Organism: Mus musculus (Mouse)
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Cytoplasmic vesicle membrane. Melanosome
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