UniprotKB/SwissProt ID: P56818 (P56818)
Gene Name:
Bace1
Organism: Mus musculus (Mouse)
Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091). Cleaves CHL1 (PubMed:29325091)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Late endosome. Early endosome. Cell surface. Cytoplasmic vesicle membrane. Membrane raft. Lysosome. Recycling endosome. Cell projection, axon. Cell projection, dendrite
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