UniprotKB/SwissProt ID: P56704 (P56704)
Gene Name:
WNT3A
Organism: Homo sapiens (Human)
Function: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix. Secreted
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