Protein Name:
Cytochrome P450 2C40
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UniprotKB/SwissProt ID: P56657 (P56657)
Gene Name:
Cyp2c40
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase that may play a major role in the metabolism of arachidonic acid in the intestinal tract (PubMed:10908295, PubMed:9721182). Exhibits regioselective hydroxylase and epoxidase activity toward arachidonic acid, producing 16(R)-hydroxyeicosatetraenoic acid (HETE) and (14R,15S)-epoxyeicosatrienoic acid (EpETrE) as major products (PubMed:10908295). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10908295)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Microsome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P56657
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
372 |
GPNGVVHEVT C DTKFRNYFIP |
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