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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Methionine--tRNA ligase, cytoplasmic
UniprotKB/SwissProt ID: P56192 (P56192)

Gene Name: MARS1

Organism: Homo sapiens (Human)

Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus, nucleolus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001412 aa-tRNA-synth_I_CS
IPR041872 Anticodon_Met
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C
IPR041598 MARS_N
IPR023458 Met-tRNA_ligase_1
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009068 uS15_NS1_RNA-bd_sf
IPR000738 WHEP-TRS_dom
The S-nitrosylation sites of P56192
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 12 RLFVSDGVPG C LPVLAAAGRA   
2 309 RLRQWNTLYL C GTDEYGTATE   
3 333 LEEGLTPQEI C DKYHIIHADI   
4 38 VLISTVGPED C VVPFLTRPKV   
5 408 DRFVEGVCPF C GYEEARGDQC   
6 441 KKPQCKVCRS C PVVQSSQHLF   
7 66 GNYLFSTSAI C RYFFLLSGWE