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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Exportin-2
UniprotKB/SwissProt ID: P55060 (P55060)

Gene Name: CSE1L

Organism: Homo sapiens (Human)

Function: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
IPR005043 XPO2_C
IPR013713 XPO2_central
The S-nitrosylation sites of P55060
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 195 TNLFKATIEL C STHANDASAL  CCCCHHHHHH H HHHHHHHCCC  2.6%
2 272 GLLELLKSQI C DNAALYAQKY  CCCCHHHHHH H HHHHHHHCCC  2.27%
3 344 FEDQNTLTSI C EKVIVPNMEF  CCCCHHHHHH H HHHHHHHCCC  4.08% 19483679
4 387 SDIDTRRRAA C DLVRGLCKFF  CCCCHHHHHH H HHHHHHHCCC  3.97% 19483679
5 61 EKSQDNVIKV C ASVTFKNYIK  CCCCHHHHHH H HHHHHHHCCC  1.66%
6 842 KVSGNVEKKI C AVGITKLLTE  CCCCHHHHHH H HHHHHHHCCC  3.26%
7 85 RIVEDEPNKI C EADRVAIKAN  CCCCHHHHHH H HHHHHHHCCC  3.63%
8 853 AVGITKLLTE C PPMMDTEYTK  CCCCHHHHHH H HHHHHHHCCC  3.74%
9 939 AQSLHKLSTA C PGRVPSMVST  CCCCHHHHHH H HHHHHHHCCC  3.58% 19483679