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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Delta-1-pyrroline-5-carboxylate synthase
UniprotKB/SwissProt ID: P54886 (P54886)

Gene Name: ALDH18A1

Organism: Homo sapiens (Human)

Function: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion. Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036393 AceGlu_kinase-like_sf
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR001048 Asp/Glu/Uridylate_kinase
IPR020593 G-glutamylP_reductase_CS
IPR041744 G5K_ProBA
IPR001057 Glu/AcGlu_kinase
IPR005715 Glu_5kinase/COase_Synthase
IPR019797 Glutamate_5-kinase_CS
IPR000965 GPR_dom
IPR005766 P5_carboxy_syn
The S-nitrosylation sites of P54886
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 546 VNTREEVEDL C RLDKMIDLII  CCCCHHHCCC C CCCCCCCCHH  6.67%
2 584 IPVMGHSEGI C HMYVDSEASV  CCCCHHHCCC C CCCCCCCCHH  1.91%
3 606 KVTRLVRDSK C EYPAACNALE  CCCCHHHCCC C CCCCCCCCHH  7.59% 19483679
4 612 RDSKCEYPAA C NALETLLIHR  CCCCHHHCCC C CCCCCCCCHH  3.12% 19483679
5 674 LRTEYGDLEL C IEVVDNVQDA  CCCCHHHCCC C CCCCCCCCHH  1.49%
6 88 GSAVVTRGDE C GLALGRLASI  CCCCHHHCCC C CCCCCCCCHH  6.87%