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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial

UniprotKB/SwissProt ID: P54868 (P54868)

Gene Name: HMGCS2

Organism: Homo sapiens (Human)

Function: Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000590 HMG_CoA_synt_AS
IPR013746 HMG_CoA_synt_C_dom
IPR013528 HMG_CoA_synth_N
IPR010122 HMG_CoA_synthase_euk
IPR016039 Thiolase-like

The S-nitrosylation sites of P54868

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 305 LQYMIFHTPF C KMVQKSLARL  CCCCHHHHHH H HHHHHHHHHC  2.68% 25040305