Protein Name:
Tyrosine--tRNA ligase, cytoplasmic
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UniprotKB/SwissProt ID: P54577 (P54577)
Gene Name:
YARS1
Organism: Homo sapiens (Human)
Function: Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P54577
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
250 |
DVKKKLKKAF C EPGNVENNGV |
CCCCCCHHHH H HHHHHCHHHH |
8.03% |
19483679
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| 2 |
424 |
ELQDRLVVVL C NLKPQKMRGV |
CCCCCCHHHH H HHHHHCHHHH |
3.66% |
37478858
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| 3 |
442 |
RGVESQGMLL C ASIEGINRQV |
CCCCCCHHHH H HHHHHCHHHH |
2.16% |
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| 4 |
501 |
LQADFKISEE C IAQWKQTNFM |
CCCCCCHHHH H HHHHHCHHHH |
2.47% |
19483679
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| 5 |
519 |
NFMTKLGSIS C KSLKGGNIS- |
CCCCCCHHHH H HHHHHCHHHH |
3.11% |
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