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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Arginine--tRNA ligase, cytoplasmic

UniprotKB/SwissProt ID: P54136 (P54136)

Gene Name: RARS1

Organism: Homo sapiens (Human)

Function: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd

The S-nitrosylation sites of P54136

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 115 SQQAKFGDYQ C NSAMGISQML  CCHHHHHHHH H HHHCHHHHHH  3.37%
2 150 NITKHLPDNE C IEKVEIAGPG  CCHHHHHHHH H HHHCHHHHHH  6.45%
3 293 EEEFKKRAYQ C VVLLQGKNPD  CCHHHHHHHH H HHHCHHHHHH  1.17%
4 312 PDITKAWKLI C DVSRQELNKI  CCHHHHHHHH H HHHCHHHHHH  6.48%
5 34 AEIDRLKNCG C LGASPNLEQL  CCHHHHHHHH H HHHCHHHHHH  3.27%
6 369 DGRKIVFVPG C SIPLTIVKSD  CCHHHHHHHH H HHHCHHHHHH  2.46% 19483679
7 502 NAAQTSVAYG C IKYADLSHNR  CCHHHHHHHH H HHHCHHHHHH  1.26%