Protein Name:
Protein transport protein Sec24C
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UniprotKB/SwissProt ID: P53992 (P53992)
Gene Name:
SEC24C
Organism: Homo sapiens (Human)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle, COPII-coated vesicle membrane. Endoplasmic reticulum membrane. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P53992
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
376 |
QGNASPRYIR C TSYNIPCTSD |
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| 2 |
383 |
YIRCTSYNIP C TSDMAKQAQV |
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| 3 |
816 |
LLQCALLYTS C AGQRRLRIHN |
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| 4 |
831 |
RLRIHNLALN C CTQLADLYRN |
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| 5 |
842 |
CTQLADLYRN C ETDTLINYMA |
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| 6 |
875 |
KAVRDTLITQ C AQILACYRKN |
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