Protein Name:
Matrix metalloproteinase-14
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UniprotKB/SwissProt ID: P53690 (P53690)
Gene Name:
Mmp14
Organism: Mus musculus (Mouse)
Function: Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed:10520996, PubMed:10737763). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (PubMed:10520996, PubMed:10737763). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed:10737763). Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity). Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1 (By similarity). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (By similarity). Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (PubMed:35177851)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Melanosome. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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