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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Methionine aminopeptidase 1

UniprotKB/SwissProt ID: P53582 (P53582)

Gene Name: METAP1

Organism: Homo sapiens (Human)

Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
IPR031615 Zfn-C6H2

The S-nitrosylation sites of P53582

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 179 AVHLACIARN C YPSPLNYYNF   
2 202 SCCTSVNEVI C HGIPDRRPLQ   
3 25 SSEAKLQCPT C IKLGIQGSYF   
4 368 EHTLLVTDTG C EILTRRLDSA   
5 40 IQGSYFCSQE C FKGSWATHKL   
6 9 --MAAVETRV C ETDGCSSEAK