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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: ATP-citrate synthase
UniprotKB/SwissProt ID: P53396 (P53396)

Gene Name: ACLY

Organism: Homo sapiens (Human)

Function: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR014608 ATP-citrate_synthase
IPR017440 Cit_synth/succinyl-CoA_lig_AS
IPR032263 Citrate-bd
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR036969 Citrate_synthase_sf
IPR033847 Citrt_syn/SCS-alpha_CS
IPR003781 CoA-bd
IPR036291 NAD(P)-bd_dom_sf
IPR017866 Succ-CoA_synthase_bsu_CS
IPR005811 SUCC_ACL_C
IPR016102 Succinyl-CoA_synth-like
The S-nitrosylation sites of P53396
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1040 GVAFVDMLRN C GSFTREEADE  CCCHHHHHHH C HHHHHHHHHC  3.79%
2 20 TGKELLYKFI C TTSAIQNRFK  CCCHHHHHHH C HHHHHHHHHC  3.7%
3 229 AKVDATADYI C KVKWGDIEFP  CCCHHHHHHH C HHHHHHHHHC  3.18% 19483679
2212679
4 519 VQGMLDFDYV C SRDEPSVAAM  CCCHHHHHHH C HHHHHHHHHC  1.94%
5 633 PATVGGIKPG C FKIGNTGGML  CCCHHHHHHH C HHHHHHHHHC  4.21% 37478858
6 845 RKPASFMTSI C DERGQELIYA  CCCHHHHHHH C HHHHHHHHHC  4.44%