Protein Name:
Tricarboxylate transport protein, mitochondrial
|
UniprotKB/SwissProt ID: P53007 (P53007)
Gene Name:
SLC25A1
Organism: Homo sapiens (Human)
Function: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:29031613, PubMed:29238895). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate (PubMed:29031613). In the cytoplasm citrate is important in the regulation of glycolysis through a feedback mechanism and in the production of acetyl-CoA which is needed for the synthesis of fatty acids, sterols, prostaglandins, dolichol and coenzyme Q (CoQ). Required for proper neuromuscular junction formation (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion inner membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P53007
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
262 |
EAHKYRNTWD C GLQILKKEGL |
CCCCCCHHHH H HHCCCCCCCC |
4.4% |
|
| 2 |
70 |
HPPRYRGIGD C VRQTVRSHGV |
CCCCCCHHHH H HHCCCCCCCC |
1.98% |
24105792
|
|
