Protein Name:
Nuclear pore complex protein Nup98-Nup96
|
UniprotKB/SwissProt ID: P52948 (P52948)
Gene Name:
NUP98
Organism: Homo sapiens (Human)
Function: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134) (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus membrane. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Nucleus membrane
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P52948
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1027 |
PSKADTSQEI C SPRLPISASH |
|
|
|
| 2 |
1068 |
FLSPSVSVQE C RTPRAASLMN |
|
|
|
| 3 |
1312 |
RRRAFSRWLS C TATPQIEEEV |
|
|
|
| 4 |
1464 |
QNTSDSDRYA C SPLPSYLEGS |
|
|
|
| 5 |
1492 |
QNSQTPLRDV C FHLLKLYSDR |
|
|
|
| 6 |
1590 |
KAVRELLTRH C QLLETPESWA |
|
|
|
| 7 |
1636 |
MESDKHLEAL C LFKAEHWNRC |
|
|
|
| 8 |
1711 |
EMLRHIQQVD C SGNDLEQLHI |
|
|
|
| 9 |
1727 |
EQLHIKVTSL C SRIEQIQCYS |
|
|
|
| 10 |
1735 |
SLCSRIEQIQ C YSAKDRLAQS |
|
|
|
| 11 |
760 |
LAKITNEKGE C IVSDFTIGRK |
|
|
|
|
