Protein Name:
Thimet oligopeptidase
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UniprotKB/SwissProt ID: P52888 (P52888)
Gene Name:
THOP1
Organism: Homo sapiens (Human)
Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P52888
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
18 |
AGDMADAASP C SVVNDLRWDL |
CCCCCCCCCC C CCCCCCCHHH |
4.46% |
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| 2 |
246 |
TRRKVEEAFN C RCKEENCAIL |
CCCCCCCCCC C CCCCCCCHHH |
4.34% |
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| 3 |
253 |
AFNCRCKEEN C AILKELVTLR |
CCCCCCCCCC C CCCCCCCHHH |
2.56% |
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| 4 |
350 |
YMNQVEETRY C VDQNLLKEYF |
CCCCCCCCCC C CCCCCCCHHH |
2.15% |
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| 5 |
434 |
HAACFGLQPG C LRQDGSRQIA |
CCCCCCCCCC C CCCCCCCHHH |
3.44% |
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| 6 |
644 |
NSKVGMDYRS C ILRPGGSEDA |
CCCCCCCCCC C CCCCCCCHHH |
2.22% |
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| 7 |
682 |
LLSKGLQVGG C EPEPQVC--- |
CCCCCCCCCC C CCCCCCCHHH |
6.93% |
2212679
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| 8 |
689 |
VGGCEPEPQV C ---------- |
CCCCCCCCCC C CCCCCCCHHH |
3.77% |
2212679
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