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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Carnitine O-palmitoyltransferase 2, mitochondrial
UniprotKB/SwissProt ID: P52825 (P52825)

Gene Name: Cpt2

Organism: Mus musculus (Mouse)

Function: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion inner membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000542 Carn_acyl_trans
IPR042572 Carn_acyl_trans_N
IPR023213 CAT-like_dom_sf
IPR039551 Cho/carn_acyl_trans
IPR042231 Cho/carn_acyl_trans_2
The S-nitrosylation sites of P52825
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 489 YGQTVATYES C STAAFKHGRT  CCCCCCCCCC C CCCHHCCCCC  2.53% 21278135
2 512 IRPASIFTKR C SEAFVREPSK  CCCCCCCCCC C CCCHHCCCCC  4.61% 21278135
3 535 VGELQHMMAE C SKYHGQLTKE  CCCCCCCCCC C CCCHHCCCCC  2.86% 21278135
4 639 SGRNAREFLH C VQKCLEDMFD  CCCCCCCCCC C CCCHHCCCCC  3.64% 21278135
5 643 AREFLHCVQK C LEDMFDALEG  CCCCCCCCCC C CCCHHCCCCC  2.55% 21278135
6 84 DSQFRKTEVL C KDFENGIGKE  CCCCCCCCCC C CCCHHCCCCC  4.86% 21278135