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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Large ribosomal subunit protein bL12m

UniprotKB/SwissProt ID: P52815 (P52815)

Gene Name: MRPL12

Organism: Homo sapiens (Human)

Function: As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation (PubMed:23603806). When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription (PubMed:22003127). Required for POLRMT stability (PubMed:26586915)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000206 Ribosomal_bL12
IPR013823 Ribosomal_bL12_C
IPR014719 Ribosomal_bL12_C/ClpS-like
IPR008932 Ribosomal_bL12_oligo
IPR036235 Ribosomal_bL12_oligo_N_sf

The S-nitrosylation sites of P52815

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 45 RHMRSSGHQR C EALAGAPLDN