Protein Name:
Hexokinase-2
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UniprotKB/SwissProt ID: P52789 (P52789)
Gene Name:
HK2
Organism: Homo sapiens (Human)
Function: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P52789
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
158 |
LPLGFTFSFP C HQTKLDESFL |
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| 2 |
256 |
DMVEGDEGRM C INMEWGAFGD |
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| 3 |
368 |
RLGLDPTQED C VATHRICQIV |
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| 4 |
375 |
QEDCVATHRI C QIVSTRSASL |
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| 5 |
386 |
QIVSTRSASL C AATLAAVLQR |
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| 6 |
438 |
HKTVRRLVPG C DVRFLRSEDG |
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| 7 |
517 |
APVKMLPTYV C ATPDGTEKGD |
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| 8 |
628 |
KWTKGFKASG C EGEDVVTLLK |
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| 9 |
794 |
TKFLSQIESD C LALLQVRAIL |
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| 10 |
813 |
ILQHLGLEST C DDSIIVKEVC |
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| 11 |
823 |
CDDSIIVKEV C TVVARRAAQL |
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| 12 |
886 |
HETVKDLAPK C DVSFLQSEDG |
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| 13 |
909 |
KGAALITAVA C RIREAGQR-- |
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