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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Guanine nucleotide exchange factor VAV2

UniprotKB/SwissProt ID: P52735 (P52735)

Gene Name: VAV2

Organism: Homo sapiens (Human)

Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR022613 CAMSAP-like_CH_dom
IPR001715 CH_dom
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH_dom
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR055251 SOS1_NGEF_PH
IPR035880 VAV2_SH2
IPR035733 VAV2_SH3_1
IPR035732 VAV2_SH3_2

The S-nitrosylation sites of P52735

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 572 HKECLEVIPP C KFTSPADLDA