UniprotKB/SwissProt ID: P52332 (P52332)
Gene Name:
Jak1
Organism: Mus musculus (Mouse)
Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endomembrane system
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