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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Inward rectifier potassium channel 4

UniprotKB/SwissProt ID: P52189 (P52189)

Gene Name: Kcnj4

Organism: Mus musculus (Mouse)

Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Postsynaptic cell membrane. Cytoplasmic vesicle membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR014756 Ig_E-set
IPR041647 IRK_C
IPR016449 K_chnl_inward-rec_Kir
IPR003273 K_chnl_inward-rec_Kir2.3
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR040445 Kir_TM