UniprotKB/SwissProt ID: P51875 (P51875)
Gene Name:
goa-1
Organism: Caenorhabditis elegans
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135). During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle (PubMed:14534135). Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122). Involved in chemosensory responses to attractive and repellent odors detected by AWC and AWB sensory neurons, respectively (PubMed:23954825). In ASER neurons, acts downstream of glr-3 to regulate cold avoidance behavior via calcium signaling, and it may also play a role in sensing cold in the intestine (PubMed:31474366). Negatively regulates axon regeneration after injury downstream of the inhibitory compound arachidonoyl ethanolamide (AEA) by antagonizing the activation of the JNK pathway (mlk-1/mek-1/kgb-1) (PubMed:23072806). In neurons, may negatively regulate diacylglycerol (DAG) production mediated by egl-30 signaling cascade and thereby negatively regulates acetylcholine release (PubMed:22897658). Couples to the muscarinic acetylcholine receptor gar-2 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679). Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030). Involved in egg-laying and in regulating dopamine-mediated locomotion (PubMed:15378064, PubMed:8548815). Most likely couples to the dopamine receptors dop-2 and dop-3 to positively regulate the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons in the presence of food (PubMed:19609300)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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