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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peroxisomal multifunctional enzyme type 2
UniprotKB/SwissProt ID: P51660 (P51660)

Gene Name: Hsd17b4

Organism: Mus musculus (Mouse)

Function: Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway (PubMed:17442273). Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates (By similarity) (PubMed:17442273)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Peroxisome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029069 HotDog_dom_sf
IPR002539 MaoC-like_dom
IPR054357 MFE-2_N
IPR036291 NAD(P)-bd_dom_sf
IPR051687 Peroxisomal_Beta-Oxidation
IPR020904 Sc_DH/Rdtase_CS
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR002347 SDR_fam
The S-nitrosylation sites of P51660
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 175 SAAKLGILGL C NTLAIEGRKN  CCCCCEECCE E EEEECCCCHH  3.29% 21278135
2 189 AIEGRKNNIH C NTIAPNAGSR  CCCCCEECCE E EEEECCCCHH  4.21% 22178444
21278135
3 277 EAVRDNWEKI C DFSNASKPQT  CCCCCEECCE E EEEECCCCHH  6.82% 22178444