Protein Name:
Peroxisomal multifunctional enzyme type 2
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UniprotKB/SwissProt ID: P51659 (P51659)
Gene Name:
HSD17B4
Organism: Homo sapiens (Human)
Function: Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P51659
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
189 |
AIEGRKSNIH C NTIAPNAGSR |
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| 2 |
277 |
EAVKANWKKI C DFENASKPQS |
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| 3 |
373 |
FIYEGSSDFS C LPTFGVIIGQ |
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| 4 |
425 |
KPLPRAGKLK C EAVVADVLDK |
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